Enerzair Breezhaler® - Boosting Adherence to Improve Asthma Outcomes

Drug Review: Volume 21, Issue 10 - Download PDF

Asthma is a very common chronic breathing condition seen in patients of all ages and backgrounds. Asthma involves inflammation of the airways that leads to limited airflow and difficulty breathing. Symptoms of asthma include chest tightness, wheezing, coughing and breathlessness. Asthma has a significant burden on an individual physically, psychologically, and socially. In Canada, approximately 8.3% of patients suffer from asthma, and it continues to be one of the most common chronic conditions in the world.


The goal of asthma treatment is to limit the symptoms and improve breathing. The treatment of asthma usually involves a low dose-inhaled corticosteroid (ICS) that is intended for symptom control. If symptoms are still unmanaged, then a maintenance inhaler containing a long-acting beta agonist (LABA) is introduced. If asthma remains uncontrolled, then either a long-acting muscarinic antagonist (LAMA) or a leukotriene receptor antagonist (LTRA) is added on. Due to the cumulative nature of asthma treatment, regimens can become complicated, resulting in misuse of inhalers and lack of adherence. Non-adherence is one of the leading causes of uncontrolled asthma. Currently there are no products available that deliver a combination of LABA, LAMA and ICS; therefore, multiple inhalers are often necessary.

Enerzair Breezhaler® is a once-daily, fixed dose combination LABA/LAMA/ICS inhaler for the treatment of uncontrolled asthma. Enerzair Breezhaler® provides a treatment option that can boost adherence by eliminating the need for multiple inhalers, which will lead to better overall outcomes for patients.


Enerzair Breezhaler® provides a simple and effective treatment option for patients with uncontrolled asthma. The annual cost of $1,234 makes Enerzair Breezhaler® more cost effective than the combination of the alternative LABA/ICS plus LAMA inhalers. For these reasons, Enerzair Breezhaler® will be Fully Covered for both Managed and Open Formularies.

Drug Name

Enerzair Breezhaler®

Drug Ingredients



Annual Cost


Coverage Details

Fully Covered for Managed and Open formularies

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  1. Enerzair Breezhaler® Product Monograph. Novartis Pharmaceuticals Canada Inc. July 2020.
  2. Global Initiative for Asthma – Global Strategy for Asthma Management and Prevent, 2021. https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf

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